Proinflammatory cytokines VEGFA, IL-6, IL-8 as markers of hepatotoxicity after COVID-19

The mechanism of hepatocellular liver damage after COVID-19 is a multifactorial process. most widely discussed causes are cytolytic due to the inflammatory response COVID-19, drug-induced hepatotoxicity and direct cytotoxic effect virus. There observations that SARSCoV-2 infection hepatitis B virus reactivation, but little has been described about interaction between C SARS-CoV-2. course coronavirus associated with marked expression proinflammatory cytokines, participants in multisystem response, IL-1β, IL-6, IL-8, IL-18, MCP-1, TNFα, which contribute significantly observed early late function impairment. aim study was evaluate role cytokines (VEGFA, IL-18) as additional markers COVID-19. performed March August 2022. Patients were divided into 2 groups: Group 1 – increased aminotransferases against background treatment from and/or following 3-6 months disease without viral (n = 42), patients co-infection (chronic (HCV) 26). levels VEGF-A, TNFα blood serum estimated by enzyme immunoassay method. Statistical analysis using StatTech v. 3.1.4. results revealed comparable increase level transaminases C-reactive protein both groups, different reference values. Direct correlations moderate strength (linear Spearman correlation) found cytokines: TNFα-MCP-1 (R 0.559; p 0.001), TNFα-VEGFA 0.400; 0.002), TNFα-IL-6 0.503; 0.001). We diagnosed significant VEGFA group (hepatotoxicity COVID-19) (Me (Q 0.25 -Q 0.75 ): 522 (250 1002), 0.001) (HCV + 1196, Q : (73 432). Similar trend exceeding values healthy donors higher than patients. Identified prove unidirectional changes functioning regulatory network controlling immune virus-induced reactions.